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Increase baseline fluid intake by 20% and add an electrolyte supplement

Participants A total of 1545 participants (82% of all participants treated with tirzepatide in SURMOUNT1) met criteria and were included in the present analyses, with 278 (18.0%) categorized as late responders and 1267 (82.0%) categorized as early responders

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Abstract 10370: Effects of tirzepatide on 24-hour ambulatory blood pressure and heart rate in adults with obesity - results from the SURMOUNT-1 ambulatory blood pressure monitoring sub-study

Many researchers find their optimal response at 5 mg per week and never need to titrate higher

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