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To further examine the effects of SGLT2is alone or SGLT2is + DPP4is on ENaC expression levels in the kidneys, we analyzed renal biopsy specimens obtained from DKD patients

SGLT-2 Inhibitors and GLP-1 Receptor Agonists as Combination Therapy in Type 2 Diabetes

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In other words, the trial data points to a gradual curve, not a quick spike
Notably, IR was independently associated not only with the presence of ED but also with its severity [49]
