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Tirzepatide is a dual-agonist that activates both GLP-1 and GIP receptors

Major progress has been made in the GLP-1 combination front with long-acting amylin analogues and a better understanding of the tolerability events that have limited development of PYY therapeutics

Another large observational study suggested tirzepatide users may lose slightly more lean mass than semaglutide users, though more research is still needed
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The experience of these side effects can vary based on dosing schedule and titration
