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Activation of this circuit in obese mice reduces food intake and improves glucose tolerance by stimulating insulin secretion via inhibition of GABA-input-dependent sympathetic nervous activity in the paraventricular hypothalamus

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Meta-analyses have confirmed that GLP-1 receptor agonists reduce cardiovascular risk while producing only minor elevations in resting heart rate

Interestingly, recent clinical studies have confirmed the glucose-lowering effects of GcgR antagonism in individuals with type 2 diabetes [54, 55]

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