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Spacing from heavy meals supports better absorption

Medical Clearance Any patient on GLP-1 medications must receive medical clearance prior to surgery

Patients with uncontrolled diabetes should not take semaglutide

There is evidence that the use of dipeptidyl peptidase-4 inhibitors (DPP-4) (gliptins) and/or glucagon-like peptide-1 (GLP-1) mimetics is associated with a higher rate of Parkinson's disease compared with the use of other oral antidiabetic drugs 2

As an investigational peptide, any legitimate clinical use involves a licensed provider, a prescription, and compounding through a licensed pharmacy

Again, keep in mind that nausea tends to occur early in the process