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In contrast, some analyses report lower risk for specific cancers, particularly hepatocellular, colorectal, and prostate cancers

10.1002/jnr.21483 15 BlevinsT.PullmanJ.MalloyJ.YanP.TaylorK.SchulteisC.et al

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They observed that patients with T1D were more insulin resistant than their BMI-matched counterparts at the levels of the liver, skeletal muscle, and adipose tissue (31)

On the other hand, metformin-treated mice displayed a slight decrease in body weight, fat mass, and circulating glucose, insulin, and leptin levels, which was associated with a modest reduction of HOMA-IR index and a drop in daily food intake (Fig