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Amino AcidDependent Antioxidant and Anabolic Coupling Amino acid availability represents a second constraint-sensitive axis because amino acid pools support both structural maintenance and antioxidant buffering

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doi: 10.1038/s12276-018-0084-3 29 KangZ.ZengJ.ZhangT.LinS.GaoJ.JiangC.et al

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however, based on thyroid C-cell hyperplasia, adenomas, and medullary thyroid carcinomas observed in studies of these agents in mice (40), all of the GLP-1 receptor agonists except exenatide BID and lixisenatide are contraindicated in patients with a personal or family history of medullary thyroid carcinoma and in patients with multiple endocrine neoplasia syndrome type 2 (1418)