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In this trial, the use of semaglutide at a dose of 2.4 mg weekly was found to be superior to placebo in reducing the incidence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke [18]
There has been modeling done to explore alternative dosing regimens of GLP-1s that simultaneously reduce costs and maintain weight-loss efficacy, but theres limited evidence and no formal guidelines to support this practice, Zimmermann says

Additionally, efficacy results for orforglipron were impressive

They're on tight incomes

Typically, all of this glucose is reabsorbed, with less than 1% of filtered glucose ultimately being excreted in the urine in a person without T2DM

doi: 10.1124/jpet.119.258343
