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Dose escalation with split dosing If you are already split dosing at one level and need to escalate, increase the total weekly dose while maintaining the split

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If a physician can clearly communicate an individuals risk, explain the evidence & recommend the appropriate intervention, adoption becomes less about selling a drug & more about practicing good medicine

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In contrast, delayed gastric emptying gives medications with low solubility or dissolution rate (such as digoxin) additional time to dissolve, which may increase exposure