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Description
Iwasaki H, Kajimura M, Osawa S, Kanaoka S, Furuta T, Ikuma M, et al

It suppresses appetite and increases signals of satiety

No color change

It hangs around in your system for weeks after you stop taking it

Approved indications for GLP-1s: Cardiovascular disease Chronic kidney disease Obesity Sleep apnea Type 2 diabetes Metabolic dysfunction-associated steatohepatitis (MASH) Potential future indications: (indications with asterisks have already been investigated in randomized clinical trials) Substance use disorders (alcohol, tobacco) Alzheimers Parkinsons Cancer prevention Diabetes prevention* Diabetic retinopathy Heart failure* Osteoarthritis* Peripheral artery disease* Polycystic ovarian syndrome Psoriasis When I was at the ADAs 85th Scientific Sessions this year, what was quite apparent was just how quickly the field has progressed beyond GLP-1s

Clinical wins, safety setbacks, generics pressure, and aggressive IP maneuvering are reshaping the competitive landscape at record speed
