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Transient transfection, as above, was used to deliver DNA encoding mouse GLP-1RLgBiT and ARRB1/2-SmBiT fusion proteins

According to the World Health Organization (WHO), over 422 million people globally live with diabetes, while obesity has nearly tripled since 1975, with more than 1 billion individuals affected, significantly increasing demand for effective GLP-1-based therapeutic interventions worldwide

2072, Apr

[DOI] [PubMed] [Google Scholar] 10.Frias JP, Deenadayalan S, Erichsen L, Knop FK, Lingvay I, Macura S, et al

What the Evidence Shows So Far Preclinical Promise A major review of preclinical research mainly in cell cultures and animal models found that most GLP1 drugs significantly reduced amyloidbeta and tau accumulation and appeared to improve insulin signalling and reduce brain inflammation

[DOI] [PMC free article] [PubMed] [Google Scholar] 47.Michie S, Ashford S, Sniehotta FF, Dombrowski SU, Bishop A, French DP