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Considering the documented changes in sensitization and upregulation of TRPV1 in the complete Freunds adjuvant (CFA)-induced inflammatory pain model, CFA was utilized to induce chronic inflammatory pain in mice 43
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3d), sustained plasma Exe4 concentrations and therapeutic effects were observed in DIO mice, owing to the compensatory high gene expression at the Alb gene in hepatocytes
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Understanding the specific dose you are using helps calibrate expectations for both benefits and side effects
Husain M, Birkenfeld AL, Donsmark M, Dungan K, Eliaschewitz FG, Franco DR, Jeppesen OK, Lingvay I, Mosenzon O, Pedersen SD, et al
