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A role for GLP-1 in regulating glycaemia had been noted in 1986, when this, then newly described ( in vitro , while studies in healthy humans revealed that circulating levels of GLP-1 increased after nutrient intake and confirmed GLP-1 to be an incretin hormone in vivo ( in vitro kinetic studies ( Inhibiting DPP-4 as a Therapy for T2DM In order for this approach to be viable, DPP-4 cleavage would need to be the initial and primary route of metabolism of GLP-1

Br J Anaesth 126(3):567571

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Then, the researchers administered exendin-4 via intrathecal injection to the experimental rats and observed a reduction in pain sensitivity, alleviation of neural inflammation, and suppression of inflammatory factors such as IL-1, TNF-, and iNOS