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A standard chow diet (A04, SAFE, France) and tap water were provided ad libitum
CSF samples could be assessed by central or local laboratory, provided the local laboratory was part of the Alzheimers Association quality control program at the time of analysis
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Unlike traditional approaches that focus exclusively on calorie reduction, Retatrutide works through multiple hormone pathways involved in appetite regulation, energy balance, and glucose metabolism

It is unknown whether any of these approaches are superior

This effect may occur independently or may indicate a hyperserotonergic state