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The linker (Gly 4 Ser) 3 Ala was carefully selected to retain high GLP-1R affinity as direct fusion dramatically reduced in vitro activity by 95%

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GLP-1 receptors in the VTA and NAc modulate dopaminergic, glutamatergic, and GABAergic neurotransmission, all three major neurotransmitter systems involved in addiction

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