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Injectable weight loss medications such as tirzepatide and semaglutide have helped millions of Americans shed excess weight

When the researchers treated the mice with GLP-1 agonists, the drugs appeared to normalise fibrosis-related genes and to reprogramme the macrophages that contributed to scar tissue accumulation

In addition, peptide polyagonists (i.e., synthetic molecules that combine the amino acid sequences of more than one peptide, thus having the ability to bind to more than one receptor), such as tirzepatide (LY3298176) [a dual GLP-1RA and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist] have also been introduced into the management of metabolic diseases, including T2DM and obesity, and also are under investigation for NAFLD with high expectations [7]

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2023 Jan-

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