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Semaglutide (Ozempic, Wegovy) has become a popular obesity drug because it promotes dramatic weight loss

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Comparative Efficacy of Incretin-Based Therapies After ~48 Weeks This bar chart presents a direct comparison between Mazdutide 6 mg, Tirzepatide 15 mg, Semaglutide 2.4 mg, and Placebo across three key anthropometric outcomes: Percentage Weight Loss Tirzepatide: 15.0% Mazdutide: 14.0% Semaglutide: 12.4% Placebo: +0.3% Patients Achieving 15% Weight Loss Tirzepatide: 51.0% Mazdutide: 49.5% Semaglutide: 36.0% Placebo: 2.0% Reduction in Waist Circumference (cm) Mazdutide: 10.7 cm Tirzepatide: 9.5 cm Semaglutide: 8.5 cm Placebo: 1.4 cm Interpretation Mazdutide demonstrates comparable efficacy to tirzepatide in both absolute weight reduction and waist circumference improvement, outperforming semaglutide across these endpoints