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Obesity is the biggest risk factor for Type 2 diabetes, and substantial weight loss can help in reversal and remission of the disease, as well as reduced risk for conditions like high blood pressure, dyslipidemia, heart disease, and stroke

Due to inclusion criteria, all participants required secondary prevention of CV disease

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Subjects were always assigned the lowest available randomisation number

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Weight loss results may also vary by age, with older adults potentially experiencing smaller weight loss