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However, their use is often hampered by gastrointestinal adverse effects, with nausea being a primary concern that limits tolerability and leads many patients to abandon treatment

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Shortly after food intake, these incretins are released into body circulation and bind to their receptors

Tirzepatide demonstrates superior HbA1c reduction (2.012.30%) and weight loss (up to 11.2 kg) compared to selective GLP-1 agonists in clinical trials

To date, the U.S

Additionally, in patients with pre-existing thyroid nodules using GLP-1 analogs, approximately 9% developed thyroid cancer during follow-up, highlighting the importance of enhanced surveillance in this higher-risk population [190]