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Data described in this press release refer to the master trial and extension period

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Inflammatory cytokines, such as TNF-, IL-18, and IL-6, are significantly elevated in patients with PCOS compared with healthy individuals.16 Macrophages and lymphocytes in the ovarian tissue of PCOS patients secrete large amounts of TNF- and IL-6, resulting in inhibition of the formation of dominant follicles and apoptosis of granulosa cells

Reduced ghrelin secretion in the hypothalamus of rats due to cisplatin-induced anorexia