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But the standard dose ranges are completely different

Patients (n=281, 56% women, mean age 56 years) had type 2 diabetes of approximately 8 year-duration uncontrolled on metformin with mean baseline HbA1c of 8.3% [4]

Metformin is an inexpensive generic drug, and average costs are around $20 for a one-month supply

Subsequent studies in the journals PNAS and JAMA Network Open the latter of which was conducted using data from the Framingham Heart Study at BU found links between higher body mass index and increased mortality risk, including the cumulative effects of weight status over multiple decades

Diabetes Obes Metab (2013) 15(8):73749

Grimm M, Han J, Weaver C, Griffin P, Schulteis CT, et al