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Orforglipron, developed by Eli Lilly, is an investigational daily pill that mimics the effects of injectable GLP-1 receptor agonists, a class of drugs known to help with weight loss and blood sugar control

Waist circumference often changes faster than weight during the first month

Energy expenditure rises

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Patients taking insulin or a sulfonylurea alongside retatrutide face an increased risk of hypoglycaemia and should have a management plan agreed with their clinical team before starting

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