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Interestingly, chronic chemo-genetic stimulation of POA LepR-expressing neurons decreases both food intake and energy expenditure, and results in body weight loss, indicating that the reduced food intake surpasses the decreased energy expenditure [28]

Axe content is medically reviewed or fact checked to ensure factually accurate information

It is pharmacokinetically puzzling as an oral therapy because, as a peptide, it faces the usual hurdles of gastric degradation and poor epithelial uptake

Medicare historically has not covered anti-obesity medications, though legislative efforts are underway to change this
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