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So, we need to be aware that methodological issues may be at play

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RC-fed Dpp4 / mice exhibited no detectable plasma DPP4 activity, an approximately 8-fold increase in plasma active GLP-1, reduced fasting glucose, improved glucose tolerance, and no difference in body weight compared with Dpp4 +/+ mice (Figure 2A and Supplemental Figure 1, A and B

9 When the body loses weight, it naturally reduces some lean tissue alongside fat stores