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Exendin-4 ameliorates cardiac ischemia/reperfusion injury via caveolae and caveolins-3

Beyond improving glycemic control and promoting weight loss, GLP-1 receptor agonists have been shown to reduce vascular inflammation, improve endothelial function, enhance nitric oxide bioavailability, and reduce oxidative stress. These effects may slow the progression of atherosclerosis and improve blood flow to the lower extremities

It mimics the action of natural GLP-1, a hormone that stimulates the release of insulin and reduces the amount of glucose produced by the liver

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Freezing and thawing can change protein stability and promote aggregation, and the effect depends on the formulation. What signs mean a reconstituted vial should be discarded