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linagliptin is an exception, as it is primarily excreted via the bile and does not require renal dose adjustment

10.1056/NEJMoa2208601 149 WeiX.ShiX.ZhongW.ZhaoY.TangY.SunW.et al (2013)
Reece EA

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The main differences are simply cost and convenience

excessively low LDL could have unknown consequences
