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Description
The STEP trials (Semaglutide Treatment Effect in People with obesity) tested weekly semaglutide at 2.4 mg (a higher dose than for diabetes) in people with obesity (BMI 30 or 27+comorbidity)

Actual results may vary depending on benefit plan design, member demographics, programs implemented by the plan and other factors

Metformin increases GLP-1 secretion, which could increase insulin secretion and decrease glucagon secretion (48)

Questions about practical considerations: What is the titration schedule, and how long before I reach the target dose

Will they affect thyroid hormones
The net result: innovative drug assets originating in or licensed into China gain higher commercial value, with more predictable revenue streams and reduced risk from patent instability
