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36 Furthermore, DDIs between levothyroxine and oral semaglutide, caused by delayed gastric emptying, have been explored (Table 5)

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Although leptin primarily regulates appetite and satiety, it also has effects on glucose metabolism and fatty acid oxidation through its impact on insulin sensitivity

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Currently, the FDA-approved drugs to treat obesity are orlistat, phentermine-topiramate ER, naltrexone-bupropion, liraglutide, semaglutide, tirzetapide, and setmelanotide (Yanovski and Yanovski, 2021

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