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Simultaneously, these medications suppress glucagon secretion from pancreatic alpha cells, further contributing to improved glycemic control

Patients discontinuing GLP-1 medications should monitor for signs of gallbladder problems (severe abdominal pain, especially after meals), pancreatitis (persistent severe abdominal pain, sometimes with vomiting), or significant hyperglycemia

Why 72 hours instead of 48

The base line is, if too much of nutrition intake, particularly protein, is cut back, the body will break down muscle for fuel

Food and Drug Administration (FDA) labels alert users to a small number of rarer but more serious adverse events

Tirzepatide achieved up to 22.5% in its 72-week Phase 3 SURMOUNT-1 trial
