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Medical and Lifestyle Factors That Increase Risk Obesity is a major risk factor, as a higher body weight is associated with increased cholesterol in the bile

Kostev, 2014): Diarrhea Difficulty sleeping Dizziness Dry mouth Headache Nausea Nervousness Rapid heart rate Sexual dysfunction Tiredness Tremor Weight gain (except fluoxetine which may cause weight loss) Sexual dysfunction Sexual dysfunction is particularly bothersome, affecting 4065% of both men and women who use SSRI antidepressants

Data from the STEP-1 trial showed significant lean mass reduction alongside fat loss on semaglutide

Key Background Novo Nordisk was the first major pharmaceutical company to bring a GLP-1 to market with Wegovy in 2021

Editor in Chief, Harvard Men's Health Watch Image: IPGGutenbergUKLtd/Getty Images Disclaimer: As a service to our readers, Harvard Health Publishing provides access to our library of archived content

Biochem Biophys Res Commun 505(2):523529 Daniels SJ, Leeming DJ, Detlefsen S, Bruun MF, Hjuler ST, Henriksen K, Hein P, Karsdal MA, Brockbank S, Cruwys S (2019) Biochemical and histological characterisation of an experimental rodent model of non-alcoholic steatohepatitis - Effects of a peroxisome proliferator-activated receptor gamma (PPAR-) agonist and a glucagon-like peptide-1 analogue