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Have a history of pancreatitis as there is a slight increased risk of developing pancreatitis on this medication Have gastroparesis due to it slowing down gastric emptying which can worsen gastroparesis Have hypertriglyceridemia, or extremely high triglyceride levels As with other agents in this class, tirzepatide has a boxed warning regarding rodent thyroid C-cell tumor findings and the uncertain relevance to humans

The tradeoff with lower concentrations is that you need more liquid per dose, which means larger injection volumes and faster vial depletion

The second tells you what to do when your microdose stops working

They may also submit a letter of medical necessity

It is a 31-amino acid peptide with 97% homology to native human GLP-1 and a C16 palmitic acid chain that enables albumin binding and a 13-hour half-life

Yes, there are still challenges with access and tolerability, but these will improve with time