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Noteworthy, neither PRA nor plasma aldosterone significantly changed after six months of treatment, confirming the transient diuretic effect of SGLT2-i

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They do not account for hormonal shifts that increase cravings and fat storage

Conclusions This case underscores the potential for semaglutide, a widely used GLP-1 receptor agonist, to induce clinically significant gastroparesis, particularly in patients with pre-existing gastrointestinal comorbidities and when proper dose titration is not followed

Type 2 diabetes or prediabetes is another strong qualifying condition