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While norepinephrine seemingly inhibits GLP-1 secretion via its action on -adrenergic receptors, its secretion is stimulated by isoproterenol, and this effect can be blocked by co-infusion of the -adrenergic receptor antagonist propanolol [337]

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And a small randomized clinical trial found patients with opioid use disorder who took an older form of GLP-1 known as liraglutide experienced a 40 percent reduction in opioid cravings compared with a placebo