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Notably, GLP-1RAs can be used to reach the desired short term outcome in diabetes management: effective glucose lowering without weight gain

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Major players like Novo Nordisk, Eli Lilly, and AstraZeneca are making strategic investments

Simultaneous GLP-1 receptor activation and angiotensin receptor blockade increase natriuresis independent of altered arterial pressure in obese OLETF rats

In more serious cases they run the risk of splitting open and causing life-threatening haemorrhages, which in the 1970s was one of the most frequent reasons for emergency surgery

Exenatide protects against glucose- and lipid-induced endothelial dysfunction: evidence for direct vasodilation effect of GLP-1 receptor agonists in humans