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The production and expression of GIP is also noted in the central nervous system [18]

Nausea, diarrhea, and constipation are the most common and often lessen with time

The study authors conducted a systematic literature review and Bayesian network meta-analysis (NMA)

It is released at specific synaptic sites within the brain, exerting spatially precise signalling
This may help explain why one patient does well with a lower-dose oral option while another needs a structured weekly injection protocol to see meaningful progress

The FDA-approved maximum dose of Ozempic is 2 mg once weekly
