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In earlier studies, retatrutide reduced liver fat by more than 80% in people with metabolic fatty liver disease, with most participants no longer meeting diagnostic thresholds

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However, because glucagon-like peptide-1 receptor agonists work to slow gastric emptying, a safety concern has been raised in patients undergoing deep sedation or general anesthesia regarding gastric aspiration, and considering their long half-life in the blood, they are difficult to manage in the perioperative period