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A 2025 study in Investigative Ophthalmology & Visual Science found that GLP-1 users are more than three times more likely to develop NAION than non-users

[DOI] [PubMed] [Google Scholar] 190.Kirby M, Yu DM, O'Connor S, Gorrell MD

Red flag symptoms requiring urgent medical attention include: Signs of dehydration: excessive thirst, dark urine, dizziness, decreased urination, or confusion Severe abdominal pain, especially if localized to the right upper quadrant or accompanied by fever Blood in stool or black, tarry stools Persistent vomiting preventing adequate fluid intake Symptoms of pancreatitis: severe upper abdominal pain radiating to the back, nausea, and vomiting Rapid heart rate, weakness, or fainting Severe abdominal distension or inability to pass gas or stool (possible signs of intestinal obstruction) Seek emergency care (call 911 or go to the emergency department) for severe dehydration with confusion, fainting, or severe, unrelenting abdominal pain

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Caution Required: Both compounds are research-grade and lack long-term safety data

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