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Prioritize Protein While historic guidelines suggested people aim for 0.81 gram of lean proteins (like eggs, wild-caught fish, poultry, or grass-fed beef) per pound of body weight, Eberwein recommendsand recent science supports 7 a higher protein intake: 1.21.6 g per kilogram of body weight to blunt the muscle-loss signal during a calorie deficit, especially in midlife and older adults

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Recently approved medications include liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist (FDA approved 2020)

Triple receptor activation provides more comprehensive metabolic effects than single or dual agonists Glucagon receptor stimulation may enhance fat oxidation and spare muscle glycogen during exercise GIP receptor effects could improve nutrient partitioning towards lean tissue Clinical trials have demonstrated significant reductions in body fat percentage alongside weight loss The medication is administered via weekly subcutaneous injection, similar to other GLP-1 treatments Retatrutide and Muscle Preservation During Fat Loss One of the most pressing concerns for bodybuilders considering any weight loss medication is the potential loss of hard-earned muscle mass

Most people experience slight discomfort

Twelve weeks of exenatide treatment increases [18F]fluorodeoxyglucose uptake by brown adipose tissue without affecting oxidative resting energy expenditure in nondiabetic males
