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As GLP-1 RAs are contraindicated for people with gastrointestinal disease, pancreatitis, or a family history of mutations in multiple endocrine neoplasia type 2/medullary thyroid carcinoma (MEN2/MTC), SGLT2i is the preferred treatment for these patients groups

Body weight and composition can influence drug distribution and pharmacokinetics

Results of this and future studies could offer a promising new way to help reduce the risk of colorectal cancer before it develops

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One significant advantage of GLP-1 agonists, including semaglutide, over earlier generations of diabetes drugs is their minimal risk of causing hypoglycemia (Collins & Costello, 2023)