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Scenario D: Unintended Pregnancy During GLP-1RA Therapy (Safety Management) Background: unintended conception may occur during GLP-1RA-assisted weight-loss treatment, particularly if contraception is inconsistent during dose escalation or periods of improved cycle regularity

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268 Physiologic GLP-1 secretion is a complex, incompletely understood process, with early studies suggesting potentiated release through nutrient supplementation, whole foods, dietary patterns, and microbiome alterations

The gene at chromosome 17p13.3 encoding for the human GLP-2 receptor is also very well conserved as the rat sequence is 80% of the same amino acid sequence (Shin et al., 2005)