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No GLP-1 medication has definitively fewer side effects across all userstolerability is highly individual and shaped by genetic factors, dosing escalation speed, and whether the medication is injected or oral

[89] In May 2026, the CHMP adopted a positive opinion, recommending a change to the terms of the marketing authorization for the medicinal product Wegovy

doi:10.1016/S2213-8587(19)30194-9

34,35 Subsequently, GLP-1 undergoes enzymatic degradation facilitated by dipeptidyl peptidase IV (DPP-4), leading to the loss of its biological efficacy

26 From a bioenergetics angle, the GLP-1 response is highly inefficient (GLP-1 synthesis requires ATP), due to the majority of the GLP-1 secreted being inactivated before it reaches its targets