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According to our experience in rats, the parenteral administration of ghrelin at a dose that raised plasma hormone to the level observed under fasting conditions, significantly attenuates plasma levels of leptin, while markedly increasing food intake

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Post-hoc analyses of randomized controlled trials [46] and real world evidence [47] support a complementary and thus additive cardiovascular protection achievable with the combination of GLP-1RAs and SGLT2i, but no dedicated trials have confirmed this preliminary evidence

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