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ACC/AHA guideline update for perioperative cardiovascular evaluation for noncardiac surgery--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1996 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery)

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In previous years, mounting evidence has shifted the paradigm of a long-presumed rare disease to the most common cause of endocrine hypertension and established PA as an independent risk for cardiovascular morbidity

While TIR offers a slight improvement in these adverse effects, its co-administration with DXN does not significantly counteract them

This advantage may reflect depot and sexspecific GLP1R distribution within the adipose tissue, although further studies are required to clarify this mechanism
