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doi: 10.1053/j.gastro.2011.10.032 59 SandbornWJFeaganBGMaranoCZhangHStraussRJohannsJet al
Genetics of Prader-Willi Syndrome Three distinct genetic mechanisms are responsible for PWS: approximately 65% to 70% of cases result from paternal deletion of 15q11.213, 20% to 30% are caused by maternal uniparental disomy of chromosome 15, and the remaining 2% to 5% of cases result from imprinting center defects or chromosome 15 rearrangement [1519]
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