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Improvement of high fat-diet-induced insulin resistance in dipeptidyl peptidase IV-deficient Fischer rats

Laboratory values were only available in a minority of patients since most cases were followed in the home setting, so it is possible that the incidence of hypoglycemia was underestimated

Subsequent preclinical experiment in the same study demonstrated that under high-glucose conditions, exendin-4 reduced phosphorylation of P65 and IB, downregulated PSMA2 expression, inhibited the NF-B pathway, suppressed cell proliferation, and reduced tumor volume in vivo

Second, several studies suggested that patients with T2D were insensitive to the insulinotropic actions of GIP, while GLP-1 was a potent insulin secretagogue in these participants 28

, Gorelik, J

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