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Appleton highlighted several important remaining gaps in the understanding of GLP-1-based therapies for OA

Testing Tip: We generally recommend a 9am sample for thyroid testing

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Effect of Dipeptidyl Peptidase-4 Inhibitors on Heart Failure: A Meta-Analysis of Randomized Clinical Trials

Therefore, it is important to stay up to date with the latest recommendations from regulatory agencies and consult with a healthcare professional who can provide the most current information on dosing and titration schedules

Furthermore, the relative balance of GIPR versus GLP-1R agonism is different between NNC00902764 and tirzepatide, with the latter favoring GIPR agonism