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Supply constraints indicate demand has exceeded manufacturing capacity

The median time-to-onset of gastrointestinal AEs was 1 (IQR 024) days, and 77.44% of the AEs occurred within 30 days after excluding invalid reports

Diabetes Care (2012) 35:4857

Results from Lillys studies have shown that orforglipron can lead to major improvements in both blood sugar and weight
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Psychiatry 32 , 117127 (2024)

Phentermine at $30/month for 3 months ($90 total) producing 15 pounds of weight loss equals $6 per pound
