glp 1 drugs and thyroid Does drug affect cancer risk? Do GLP-1ra increase the risk

(Clear statement that GLP-1 RAs are not approved or proven treatments for endometriosis, despite mechanistic interest.) Fella Health He Y, et al

In human beings, it showed that soluble DPP-4 correlated with MCP-1 and up-regulation of interleukin-8 (IL-8) and interleukin-6 (IL-6), both mediators that initiate inflammation

Guggenheim also pointed out that many of the drugs under negotiation have already peaked in sales or have biosimilar or generic competition expected soon

Lean ME, Carraro R, Finer N, et al

Endocrinol Diabetes Metab 2025;8:e70019

The thinking is that a smaller amount of the drug can still trigger its effects, but on a more modest scale