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13 These findings are consistent with results from the SURPASS-1 trial, in which tirzepatide at all studied doses significantly improved HbA1c over 40 weeks without increasing hypoglycemia risk

Clock genes have been implicated in certain GI motility disorders, including gastroparesis, due to variations in circadian rhythm [66]

doi: 10.1111/j.1582-4934.2011.01451.x

Clin Geriatr Med

And for those whose weight resistance is compounded by hormonal shifts low testosterone in men or perimenopausal changes in women combining GLP-1 treatment with hormone replacement therapy for men or hormone replacement therapy for women can address both drivers at once instead of just one

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