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Each reshaped medicine, but also brought unintended consequences: overprescribing, affordability crises, and backlash when the costs or risks became undeniable

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Indeed, Versanis Bio have tried a combination of bimagrumab and semaglutide in a prior phase 2a study assessing bimagrumab in patients with obesity and type 2 diabetes

17 Conversely, findings from another population-based study suggested there was no overall increased risk of DR associated with GLP-1RA use, while a meta-analysis indicated albiglutide, a GLP-1RA no longer commercially available due to limited prescribing, was associated with an increased risk of early worsening (the four GLP-1RAs available did not exhibit a statistically significant association with DR)